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Characterization of Intrinsically Disordered Proteins from Coronavirus SARS-CoV-2


Challenge: Neurodegeneration

CSIC White books:

  • Structural bases of life and evolution of macromolecular complexity (Challenge 2; CSIC white book vol. 2)
  • Biomedicine and Health (CSIC white book vol. 4)

PI: Douglas V. Laurents & Miguel Mompeán


Intrinsically disordered proteins play essential roles regulating transcription and translation in eurkaryotic cells. Virus also have intrinsically disordered proteins and domains which they employ to subvert host processes to favor viral survival and replication. In this research line, we will use NMR spectroscopy to characterize disordered protein domains and segments from SARS-CoV-2. The goal is to obtain a better understanding of viral physiology, which could aid the development of therapeutics.


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In the image, the 3D structural model for SARS-CoV-2 Orf 6 protein predicted utilizing the program “Quark” by Xu & Zhange (2013) Proteins 81:229. This protein, which is thought to interfere with host interferon defenses, has a disordered C-terminal region (shown in red).



Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
Altincekic N, Korn SM, Qureshi NS, et al.
Front Mol Biosci. 2021 May 10;8:653148. doi: 10.3389/fmolb.2021.653148. eCollection 2021. PMID: 34041264



  • COV20/00764 (Spanish Institute of Health Carlos III / Spanish Ministry of Science & Innovation (ISCIII / Ministerio de Ciencia e Innovación)

    Coronavirus image credit: CDC·USA/ Alissa Eckert & Dan Higgins