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Characterization of Intrinsically Disordered Proteins from Coronavirus SARS-CoV-2 |
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Challenge: Neurodegeneration CSIC White books:
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Intrinsically disordered proteins play essential roles regulating transcription and translation in eurkaryotic cells. Virus also have intrinsically disordered proteins and domains which they employ to subvert host processes to favor viral survival and replication. In this research line, we will use NMR spectroscopy to characterize disordered protein domains and segments from SARS-CoV-2. The goal is to obtain a better understanding of viral physiology, which could aid the development of therapeutics.
In the image, the 3D structural model for SARS-CoV-2 Orf 6 protein predicted utilizing the program “Quark” by Xu & Zhange (2013) Proteins 81:229. This protein, which is thought to interfere with host interferon defenses, has a disordered C-terminal region (shown in red).
Publications Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
Front Mol Biosci. 2021 May 10;8:653148. doi: 10.3389/fmolb.2021.653148. eCollection 2021. PMID: 34041264
SARS-CoV-2 Nsp8 N-terminal domain dimerizes and harbors autonomously folded elements
Treviño MÁ, Pantoja-Uceda D, Laurents DV, Mompeán M.
bioRxiv
Towards targeting the disordered SARS-CoV-2 nsp2 C-terminal region: partial structure and dampened mobility revealed by NMR spectroscopy
Mompeán M, Treviño MÁ , Laurents DV
BioRxiv
Collaborators Financing
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